Dyadic Data Analysis with R

Part I: Conceptual Foundations

Pascal Küng
Turu Stadler

Introduction

  • Turu & Pascal
  • Tell us about you and your dyadic data!
    • Name, affiliation & career stage
    • Your dyadic data and RQ

Today’s Aims and Program

Time Focus
11:00–12:45 Introduction and types of dyadic models
12:45–14:00 Lunch break
14:00–15:30 Estimating cross-sectional models in R
15:30–15:45 Short break
15:45–16:45 Intensive longitudinal extensions
16:45–17:00 Short break
17:00–18:00 Exercises in R

Introduction

Relevance and todays’ example dataset

Why dyadic data?

“Much of what we think, do, and feel is determined not by who we are but by whom we are with.” (Kenny & Cook, 1999, p. 446)

  • Partners matter: An outcome may depend on both my characteristics and my partner’s characteristics.
  • Some constructs and processes are dyadic: Shared contexts and interdependence processes can make partners’ outcomes correlated.
  • The configuration matters: Partners’ similarity, or complementarity (differences) may predict outcomes beyond either individual score.

Kenny & Cook (1999); Iida et al. (2018)

Introducing today’s dyadic dataset!

  • 38 physically inactive opposite-sex romantic couples
  • Both partners intended to increase their physical activity together
  • Smartphone-based planning interventions and JITAIs
  • Daily diaries over 55 days

Küng et al. (2026); Höhener et al. (2026)

Research Question 1

RQ1: In romantic couples, how is provided health-related social support linked to physical activity?

Measurement - Predictor

Emotional support provided

Rough English translation of the original German item
“How much did you emotionally support your partner today so that they would be physically active with greater enjoyment?”

Adapted from Bolger et al. (2000)

0 = not at all today
5 = very much today

Measurement - Outcome

Moderate to vigorous physical activity (MVPA)

Rough English translation of the original German item
“How many minutes did you spend engaging in moderate-to-vigorous physical activity today?” Adapted from Amireault & Godin (2015)

  • Alone: _____ minutes
  • Together with your partner: _____ minutes

Total MVPA = solo MVPA + joint MVPA.

Aggregating for cross-sectional examples

To show simple dyadic models we aggregate the daily diary data to obtain a “cross-sectional” dataset.

library(dplyr)

pilot_aggregated <- pilot |>
  group_by(couple_id, person_id, role) |>
  summarise(
    across(where(is.numeric), ~ mean(.x, na.rm = TRUE)),
    .groups = "drop"
  )

The variables now represent person-level daily averages across the study:

  • provided_emotional_support: average daily support provided
  • mvpa_total: average daily total MVPA (minutes)

Plotting provided support by partner role

support_distribution_plot <- ggplot(
  pilot_aggregated,
  aes(provided_emotional_support, y = after_stat(density))
) +
  geom_histogram(
    bins = 15, boundary = 0,
    fill = "steelblue", color = "white", alpha = 0.75
  ) +
  geom_density(
    bounds = c(0, Inf), color = "navy", linewidth = 1.1
  ) +
  facet_wrap(~role, nrow = 1) +
  labs(x = "Average provided support", y = "Density") +
  see::theme_modern(base_size = 16)

Provided support by partner role

Histograms and boundary-corrected density curves of average provided emotional support, shown separately for female and male partners.

MVPA by partner role

Histograms and boundary-corrected density curves of average daily MVPA, shown separately for female and male partners.

Different types of dyadic models

One model dominates dyadic research

A horizontal bar showing that more than 85% of 998 coded dyadic studies used an APIM or APIM variant, leaving fewer than 15% for all other model specifications combined.

Preliminary results from an ongoing systematic review (APIM use coded for \(n = 998\) eligible articles)

(Sakaluk et al., 2025, p. 5).

Many models to choose from

Various dyadic models can be used, each answering different questions!

  • Actor-partner interdependence model (APIM): interdependent individuals
  • Dyad-individual model (DIM) and dyadic score model (DSM): within- and between dyad associations
  • Common fate model (CFM): latent dyadic process

Other approaches include the mutual-influence model, for reciprocal influence between partners (Iida et al., 2018, p. 61), and the Truth and Bias model, for separating mean-level bias from correlational accuracy in judgments of a partner (Kenny & Acitelli, 2001; West & Kenny, 2011).

Many models to choose from

Various dyadic models can be used, each answering different questions!

  • Actor-partner interdependence model (APIM): interdependent individuals
  • Dyad-individual model (DIM) and dyadic score model (DSM): within- and between dyad associations
  • Common fate model (CFM): latent dyadic process

Other approaches include the mutual-influence model, for reciprocal influence between partners (Iida et al., 2018, p. 61), and the Truth and Bias model, for separating mean-level bias from correlational accuracy in judgments of a partner (Kenny & Acitelli, 2001; West & Kenny, 2011).

The distinguishable APIM

Conceptual distinguishable APIM with actor and partner paths.

Actor and partner effects together explain some of the covariance between partners’ outcomes.

The distinguishable APIM

Conceptual distinguishable APIM with role-specific actor and partner paths.

Actor and partner effects together explain some of the covariance between partners’ outcomes. \(\rightarrow\) But some covariance may remain!

How to estimate actor and partner effects?

Conceptually, we are esimating these two equations in a single model:

\[ \begin{gathered} \\[0.5em] Y_{\mathrm{male},i} = b_{0,\mathrm{M}} + b_{1,\mathrm{M}} \times X_{\mathrm{male},i} + b_{2,\mathrm{M}} \times X_{\mathrm{female},i} + \epsilon_{\mathrm{male},i} \\[2em] Y_{\mathrm{female},i} = b_{0,\mathrm{F}} + b_{1,\mathrm{F}} \times X_{\mathrm{female},i} + b_{2,\mathrm{F}} \times X_{\mathrm{male},i} + \epsilon_{\mathrm{female},i} \end{gathered} \]
Could we just use two separate models?

Could we just use two separate models?

Male model

male_model <- glmmTMB(
  
  outcome_male ~ X_male + X_female,
  
  data = data
)


Female model

female_model <- glmmTMB(
  
  outcome_female ~ X_female + X_male,
  
  data = data
) 

Could we just use two separate models?

Yes, we could! But then we:

  • can’t test whether the two actor effects or partner effects are equal
  • can’t pool equal paths into a shared estimate, which can increase power
  • ignore unmodelled sources of interdependence between partners
    • joint modelling tells us how much interdependence remains after accounting for the predictors

Residual interdependence in the distinguishable APIM

Conceptual distinguishable APIM with role-specific actor and partner paths.

What remains after prediction?

One linked set of dyads: changing a variance rescales one partner's residuals while preserving ρεF εM; changing ρεF εM preserves both residual variances. The correlation guide is scale-free, not a fitted regression line.

Fitting the distinguishable APIM

Fitted distinguishable APIM for provided support and MVPA.

The exchangeable APIM

Sometimes:

  • partners may not be theoretically meaningfully distinguishable
  • no evidence of difference in effects \(\rightarrow\) pool effects for greater power
  • we want to formally test distinguishability

\(\rightarrow\) Then, we may fit an exchangeable model that imposes symmetry

The exchangeable APIM

Conceptual exchangeable APIM with pooled actor and partner paths.

The exchangeable APIM

Conceptual exchangeable APIM with pooled actor and partner paths.

Exchangeability constraints

Distinguishable and exchangeable APIM equations, predictions, and residual constraints.

Fitting the exchangeable APIM

Fitted exchangeable APIM for provided support and MVPA.

Testing exchangeability

library(interdep)

compare_interdep_models(
  exchangeable_apim,
  distinguishable_apim
)
Likelihood-ratio test for nested models fitted to equivalent interdep data
Assumes mathematical nesting and an appropriate chi-squared reference distribution.

                     Df    AIC    BIC  logLik deviance  Chisq Chi Df Pr(>Chisq)
exchangeable_apim     5 617.55 628.94 -303.78   607.55                         
distinguishable_apim  9 611.59 632.08 -296.80   593.59 13.962      4   0.007418
                       
exchangeable_apim      
distinguishable_apim **
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Conclusion (5% level): The likelihood-ratio test provides evidence that `distinguishable_apim` fits better than `exchangeable_apim` (p = 0.00742).

The DIM

  • A re-parametrization of the APIM!
  • We decompose predictors into two variables:
    • Dyad mean (GM-centered): \(\bar{X} - \mu_{X}\)
    • Within-dyad member deviation: \(X_i - \bar{X}\)

In other words, these predictors express:

  • A couple’s average level compared with the average of all couples
  • A partner’s level compared with the average of their couple

DIM predictors are APIM predictors in disguise!

Provided support coordinates
APIM coordinates
DIM coordinates
xmean = (xactor + xpartner) / 2 xdev = (xactorxpartner) / 2
APIM
DIM
APIM and DIM coordinate grid The selected point is the grand-mean reference.
bmean = a + p
bdev = ap

Drag the dot or move either set of sliders. Both equations give the same fitted change in MVPA.

The DIM

Conceptual DIM with a between-dyad path from the dyad mean and a within-dyad path from the within-dyad member deviation.

The DIM

Conceptual DIM separating the between-dyad effect of the dyad mean from the within-dyad effect of the within-dyad member deviation.

Why are the DIM residuals uncorrelated?

An elevator represents the dyad mean residual, which moves both partners together; a seesaw represents the within-dyad residual, which moves partners in opposite directions. Swapping arbitrary member labels reverses only the seesaw, requiring zero covariance under exchangeability.

Swap the arbitrary member labels: \(r_{\mathrm{M}} \mapsto r_{\mathrm{M}} \qquad r_{\mathrm{D}} \mapsto -r_{\mathrm{D}}\)

Exchangeability requires the same covariance after relabelling:

\[ \operatorname{Cov}(r_{\mathrm{M}},r_{\mathrm{D}}) = \operatorname{Cov}(r_{\mathrm{M}},-r_{\mathrm{D}}) = -\operatorname{Cov}(r_{\mathrm{M}},r_{\mathrm{D}}) \quad\Longrightarrow\quad \operatorname{Cov}(r_{\mathrm{M}},r_{\mathrm{D}})=0 \]

Zero does not mean independent partners: \(\operatorname{Cov}(e_1,e_2) =\operatorname{Var}(r_{\mathrm{M}})-\operatorname{Var}(r_{\mathrm{D}})\)

Their residual association is encoded by the relative elevator and seesaw variances.

Fitting the DIM

Fitted DIM for provided support and MVPA.

DIM to APIM coefficients

Once we fit an APIM, we have already fitted a DIM—and vice versa.

We can transform values from a fitted APIM into DIM values.

Suppose \(X_i=1\) and \(X_j=1\),

then our DIM coordinates are:

\[ X_{\mathrm{mean}}=1,\qquad X_{\mathrm{dev},i}=0. \]

So,

\[ \hat Y_i=1\times a+1\times p \]

implies

\[ \hat Y_i=1\times b_{\mathrm{mean}}+0\times b_{\mathrm{dev}} =b_{\mathrm{mean}}. \]

Therefore,

\[ b_{\mathrm{mean}}=a+p. \]

DIM to APIM coefficients

Now suppose \(X_i=1\) and \(X_j=-1\) (imagine centered values),

then the DIM coordinates are:

\[ X_{\mathrm{mean}}=0,\qquad X_{\mathrm{dev},i}=1 \]

(\(i\) is 1 higher than the mean and 2 higher than partner \(j\)).

So,

\[ \hat Y_i=1\times a+(-1)\times p \]

implies for the higher partner:

\[ \hat Y_i=0\times b_{\mathrm{mean}}+1\times b_{\mathrm{dev}} =b_{\mathrm{dev}}. \]

Therefore,

\[ b_{\mathrm{dev}}=a-p. \]

DIM to APIM coefficients

Provided support coordinates
APIM coordinates
DIM coordinates
xmean = (xactor + xpartner) / 2 xdev = (xactorxpartner) / 2
APIM
DIM
APIM and DIM coordinate grid The selected point is the grand-mean reference.
bmean = a + p
bdev = ap

Drag the dot or move either set of sliders. Both equations give the same fitted change in MVPA.

The DSM

The dyadic score model (DSM) is:

  • the unconstrained distinguishable version of the DIM

  • a re-parametrization of the distinguishable APIM

  • Just like the DIM, it estimates how predictor dyad mean and differences

  • While the DIM uses deviation from the couple mean which is opposite for each partners \(X_i - \bar{X}\), the DSM uses meaningful directed differences, e.g., \(X_\mathrm{female} - X_\mathrm{male}\).

    • This allows the estimation of cross-paths, since both partners’ values do not cancel out like in the DIM$

The DSM

Conceptual DSM with paths between predictor and outcome scores.

The DSM

Conceptual DSM linking predictor mean and difference to outcome mean and difference.

In the DSM, the seats are labelled

A seesaw with female and male seats illustrates that the DSM outcome difference has a meaningful direction. Because the labels cannot be swapped arbitrarily, the outcome mean and difference residuals may correlate.

\[ D_Y=Y_{\mathrm{F}}-Y_{\mathrm{M}} \qquad\text{and}\qquad \operatorname{Cov}(r_{\mathrm{M}},r_{\mathrm{D}})\ \text{may be non-zero.} \]

A positive \(\rho_{r_m r_d}\) means: couples whose outcomes are higher than predicted on average also tend to have a larger female–male difference than predicted.

The correlation describes a pattern across couples—not two residuals varying within one couple.

Fitting the DSM

Fitted DSM for provided support and MVPA.

Research Question 2

RQ2: In romantic couples, how is collaborative planning linked to physical activity?

Measurement - CFM predictor

Dyadic predictor: collaborative planning

Rough english translation of the original German item
“We have already planned precisely for tomorrow when, where, and how we will be physically active together.” Adapted from Scholz et al. (2008)

0 = not at all true today
to 5 = completely true today

We aggregate each person’s ratings into their average daily collaborative planning across the 55 days.

Collaborative planning by partner role

Histograms and boundary-corrected density curves of average collaborative planning, shown separately for female and male partners.

Joint MVPA by partner role

Histograms and boundary-corrected density curves of average daily joint MVPA, shown separately for female and male partners.

The CFM

Conceptual Common Fate Model with shared latent levels.

The CFM

Conceptual Common Fate Model with four observed indicator intercepts, shared latent predictor and outcome levels, and symbolic standard deviations for all four indicator residuals.

Fitted distinguishable CFM

Constraint: \(\sigma^2_{\epsilon_{Y_F}} = \sigma^2_{\epsilon_{Y_M}}\). Without it, the estimated male outcome residual variance was negative.

Fitted Common Fate Model for collaborative planning and joint MVPA, including four observed indicator intercepts and unstandardized standard deviations for all four indicator residuals.

The exchangeable CFM

Positions 1 and 2 are arbitrary. The model must be unchanged when they are swapped (Ledermann & Macho, 2009; Peugh et al., 2013).

\[ \begin{aligned} \nu_{X_1} &= \nu_{X_2}, & \nu_{Y_1} &= \nu_{Y_2} \\ \sigma^2_{\epsilon_{X_1}} &= \sigma^2_{\epsilon_{X_2}}, & \sigma^2_{\epsilon_{Y_1}} &= \sigma^2_{\epsilon_{Y_2}} \\ \operatorname{Cov}(\epsilon_{X_1},\epsilon_{Y_1}) &= \operatorname{Cov}(\epsilon_{X_2},\epsilon_{Y_2}) \end{aligned} \]

  • All four loadings remain fixed to 1.
  • Ordinary wide-data df = 6; df = 0 against the exchangeable saturated model.
  • Usual exchangeability test: \(\Delta df = 5\); here: \(\Delta df = 4\) (\(\sigma^2_{\epsilon_Y}\) is already equal).

Fitted exchangeable CFM

Fitted exchangeable Common Fate Model for collaborative planning and joint MVPA. Female and male indicator intercepts, corresponding residual variances, and same-member residual covariances are constrained to equality.

No detectable loss of fit: \(\Delta\chi^2(4) = 0.65\), \(p = .958\). Parsimony favours the exchangeable model: AIC 632.60 \(\rightarrow\) 625.25; BIC 651.60 \(\rightarrow\) 637.91.

Honorable mention: The truth and bias model

References

Amireault, S., & Godin, G. (2015). The godin–shephard leisure-time physical activity questionnaire: Validity evidence supporting its use for classifying healthy adults into active and insufficiently active categories. Perceptual and Motor Skills, 120(2), 604–622. https://doi.org/10.2466/03.27.PMS.120v19x7
Bolger, N., Zuckerman, A., & Kessler, R. C. (2000). Invisible support and adjustment to stress. Journal of Personality and Social Psychology, 79(6), 953–961. https://doi.org/10.1037/0022-3514.79.6.953
Höhener, P. S., Tobias, R., Allen, J. M., Küng, P., & Scholz, U. (2026). Effectiveness of smartphone-based dyadic interventions to increase physical activity in romantic couples: Microrandomized trial. JMIR mHealth and uHealth, 14, e67136. https://doi.org/10.2196/67136
Iida, M., Seidman, G., & Shrout, P. E. (2018). Models of interdependent individuals versus dyadic processes in relationship research. Journal of Social and Personal Relationships, 35(1), 59–88. https://doi.org/10.1177/0265407517725407
Kenny, D. A., & Acitelli, L. K. (2001). Accuracy and bias in the perception of the partner in a close relationship. Journal of Personality and Social Psychology, 80(3), 439–448. https://doi.org/10.1037/0022-3514.80.3.439
Kenny, D. A., & Cook, W. (1999). Partner effects in relationship research: Conceptual issues, analytic difficulties, and illustrations. Personal Relationships, 6(4), 433–448. https://doi.org/10.1111/j.1475-6811.1999.tb00202.x
Küng, P., Höhener, P. S., Allen, J. M., Tobias, R., & Scholz, U. (2026). Daily associations of three types of social control with physical activity, reactance, and mood in romantic couples: A dyadic intensive longitudinal study. Psychology & Health, 1–25. https://doi.org/10.1080/08870446.2026.2620453
Ledermann, T., & Macho, S. (2009). Mediation in dyadic data at the level of the dyads: A structural equation modeling approach. Journal of Family Psychology, 23(5), 661–670. https://doi.org/10.1037/a0016197
Peugh, J. L., DiLillo, D., & Panuzio, J. (2013). Analyzing mixed-dyadic data using structural equation models. Structural Equation Modeling: A Multidisciplinary Journal, 20(2), 314–337. https://doi.org/10.1080/10705511.2013.769395
Sakaluk, J. K., Joel, S., Quinn-Nilas, C., Camanto, O. J., Pevie, N. W., Tu, E., & Jorgensen-Wells, M. A. (2025). A renewal of dyadic structural equation modeling with latent variables: Clarifications, methodological advantages, and new directions. Social and Personality Psychology Compass, 19(3), e70045. https://doi.org/10.1111/spc3.70045
Scholz, U., Schüz, B., Ziegelmann, J. P., Lippke, S., & Schwarzer, R. (2008). Beyond behavioural intentions: Planning mediates between intentions and physical activity. British Journal of Health Psychology, 13(3), 479–494. https://doi.org/10.1348/135910707X216062
West, T. V., & Kenny, D. A. (2011). The truth and bias model of judgment. Psychological Review, 118(2), 357–378. https://doi.org/10.1037/a0022936

Continue with the applied tutorial

Thank you for your attention!

Continue to Part II: Applied Tutorial →

Appendix

Distinguishable APIM: residual covariance

Within-dyad residual covariance block (shared across dyads):

\[ \operatorname{Cov} \begin{pmatrix} \epsilon_{Fi} \\ \epsilon_{Mi} \end{pmatrix} = \boldsymbol{\Sigma}_{\epsilon} = \begin{bmatrix} \sigma_{\epsilon_F}^{2} & \rho_{\epsilon_F\epsilon_M}\sigma_{\epsilon_F}\sigma_{\epsilon_M} \\ \rho_{\epsilon_F\epsilon_M}\sigma_{\epsilon_F}\sigma_{\epsilon_M} & \sigma_{\epsilon_M}^{2} \end{bmatrix} \]

Residual covariance matrix for all dyads (first three shown):

\[ \boldsymbol{\Sigma}_{\mathrm{model}} = \begin{bmatrix} \boldsymbol{\Sigma}_{\epsilon} & \boldsymbol{0} & \boldsymbol{0} & \cdots \\ \boldsymbol{0} & \boldsymbol{\Sigma}_{\epsilon} & \boldsymbol{0} & \cdots \\ \boldsymbol{0} & \boldsymbol{0} & \boldsymbol{\Sigma}_{\epsilon} & \cdots \\ \vdots & \vdots & \vdots & \ddots \end{bmatrix} \]

Exchangeable APIM: residual covariance

For arbitrary member positions 1 and 2, the residual variances must be equal:

\[ \operatorname{Cov} \begin{pmatrix} \epsilon_{1i} \\ \epsilon_{2i} \end{pmatrix} = \boldsymbol{\Sigma}_{\epsilon,\mathrm{exch}} = \begin{bmatrix} \sigma_{\epsilon}^{2} & \rho_{\epsilon_1\epsilon_2}\sigma_{\epsilon}^{2} \\ \rho_{\epsilon_1\epsilon_2}\sigma_{\epsilon}^{2} & \sigma_{\epsilon}^{2} \end{bmatrix} \]

  • The equal diagonal elements express exchangeability.
  • The off-diagonal element still allows residual interdependence.
  • Across dyads, these blocks form the same block-diagonal model matrix as on the previous slide.

DIM: residual covariance

\[ \begin{aligned} r_{\mathrm{M}i} &= \bar{\epsilon}_i = \frac{\epsilon_{1i}+\epsilon_{2i}}{2}, \\ r_{\mathrm{D},mi} &= \epsilon_{mi}-r_{\mathrm{M}i} \quad (m=1,2), \qquad r_{\mathrm{D},1i} = \frac{\epsilon_{1i}-\epsilon_{2i}}{2} = -r_{\mathrm{D},2i}. \end{aligned} \]

Using the arbitrary orientation \(r_{\mathrm{D}i}=r_{\mathrm{D},1i}\), exchangeability gives:

\[ \operatorname{Cov} \begin{pmatrix} r_{\mathrm{M}i} \\ r_{\mathrm{D}i} \end{pmatrix} = \begin{bmatrix} \sigma_{r_\mathrm{M}}^{2} & 0 \\ 0 & \sigma_{r_\mathrm{D}}^{2} \end{bmatrix}. \]

Back-transform to the exchangeable APIM: partner covariance need not be zero.

\[ \begin{bmatrix} \color{#1769AA}{\sigma_{r_\mathrm{M}}^{2}+\sigma_{r_\mathrm{D}}^{2}} & \color{#7B3FA1}{\sigma_{r_\mathrm{M}}^{2}-\sigma_{r_\mathrm{D}}^{2}} \\[0.35em] \color{#7B3FA1}{\sigma_{r_\mathrm{M}}^{2}-\sigma_{r_\mathrm{D}}^{2}} & \color{#1769AA}{\sigma_{r_\mathrm{M}}^{2}+\sigma_{r_\mathrm{D}}^{2}} \end{bmatrix} = \begin{bmatrix} \color{#1769AA}{\sigma_{\epsilon}^{2}} & \color{#7B3FA1}{\rho_{\epsilon_1\epsilon_2}\sigma_{\epsilon}^{2}} \\[0.35em] \color{#7B3FA1}{\rho_{\epsilon_1\epsilon_2}\sigma_{\epsilon}^{2}} & \color{#1769AA}{\sigma_{\epsilon}^{2}} \end{bmatrix}. \]

DSM: residual covariance

With distinguishable roles, the directed difference may covary with the mean:

\[ r_{\mathrm{M}i}=\frac{\epsilon_{Fi}+\epsilon_{Mi}}{2}, \qquad r_{\mathrm{D}i}=\epsilon_{Fi}-\epsilon_{Mi}. \]

\[ \operatorname{Cov} \begin{pmatrix} r_{\mathrm{M}i} \\ r_{\mathrm{D}i} \end{pmatrix} = \begin{bmatrix} \sigma_{r_\mathrm{M}}^{2} & \rho_{r_\mathrm{M}r_\mathrm{D}} \sigma_{r_\mathrm{M}}\sigma_{r_\mathrm{D}} \\ \rho_{r_\mathrm{M}r_\mathrm{D}} \sigma_{r_\mathrm{M}}\sigma_{r_\mathrm{D}} & \sigma_{r_\mathrm{D}}^{2} \end{bmatrix}. \]

Back-transform to the distinguishable APIM, with \(c_{\mathrm{MD}} =\rho_{r_\mathrm{M}r_\mathrm{D}} \sigma_{r_\mathrm{M}}\sigma_{r_\mathrm{D}}\).

\[ \begin{bmatrix} \color{#1769AA}{ \sigma_{r_\mathrm{M}}^{2}+\frac{1}{4}\sigma_{r_\mathrm{D}}^{2}+c_{\mathrm{MD}}} & \color{#7B3FA1}{ \sigma_{r_\mathrm{M}}^{2}-\frac{1}{4}\sigma_{r_\mathrm{D}}^{2}} \\[0.35em] \color{#7B3FA1}{ \sigma_{r_\mathrm{M}}^{2}-\frac{1}{4}\sigma_{r_\mathrm{D}}^{2}} & \color{#B45309}{ \sigma_{r_\mathrm{M}}^{2}+\frac{1}{4}\sigma_{r_\mathrm{D}}^{2}-c_{\mathrm{MD}}} \end{bmatrix} = \begin{bmatrix} \color{#1769AA}{\sigma_{\epsilon_F}^{2}} & \color{#7B3FA1}{ \rho_{\epsilon_F\epsilon_M}\sigma_{\epsilon_F}\sigma_{\epsilon_M}} \\[0.35em] \color{#7B3FA1}{ \rho_{\epsilon_F\epsilon_M}\sigma_{\epsilon_F}\sigma_{\epsilon_M}} & \color{#B45309}{\sigma_{\epsilon_M}^{2}} \end{bmatrix}. \]

Universität Zürich Charité – Universitätsmedizin Berlin
Summer School 2026